SRC Medical Biology and Biochemistry

The Student Research Club (SRC) of Medical Biology and Biochemistry focuses its scientific activities on a broad range of topics in medical biology and biochemistry. Special emphasis is placed on research into central nervous system diseases, such as strokes and neurodegenerative disorders, including Parkinson’s and Alzheimer’s disease. Additionally, members of the club explore issues related to oncology, concentrating on various aspects of tumors and their biomarkers. The SRC is also involved in studying the mechanisms of oxidative stress and the role of antioxidants. Another key area of research includes the endocrine function of adipose tissue and the influence of adipokines on homeostasis, as well as the role of melatonin and vitamin D in various physiological and pathological processes. Additionally, the research covers the analysis of inflammatory markers and the mechanisms of inflammatory processes.

Members of the SRC actively engage in research projects and present their findings at numerous scientific conferences both nationally and internationally. They participate in symposiums, workshops, and scientific meetings, gaining valuable experience in presenting their research. The achievements of the students are also published in peer-reviewed international journals.

The club’s research activities also include practical laboratory sessions, where students acquire essential skills in working with modern research methods. They perform biochemical assays using advanced techniques such as spectrophotometric and immunoenzymatic methods (ELISA).

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Student Research Club of Medical Biology and Biochemistry operates under the Department of Medical Biology and Biochemistry (address: Karłowicza 24 Street, 85-092 Bydgoszcz).

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Students interested in participating in the Student Research Club of Medical Biology and Biochemistry are encouraged to contact the supervisors or the representative of the scientific club.

Supervisors:

  • Karolina Szewczyk-Golec, PhD, prof. UMK (email: karosz@cm.umk.pl)
  • Jarosław Nuszkiewicz, PhD (email: jnuszkiewicz@cm.umk.pl)

Representative: Julia Markiel (email: markiel.julia1@gmail.com)

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Selected Achievements of the Student Research Club of Medical Biology and Biochemistry:

In the academic year 2023/2024, the Student Research Club (SRC) of Medical Biology and Biochemistry achieved 2nd place in the category of Best Student Research Club at the Faculty of Medicine of CM UMK, and 4th place among all Student Research Clubs operating at CM UMK.

  1. Titles of research projects carried out as part of Student Scientific Research:
  • Assessment of melatonin levels against the backdrop of neuroinflammation in patients with ischemic stroke
  • Assessment of tumor necrosis factor-alpha and interleukin 31 levels against the backdrop of neuroinflammation in patients with ischemic stroke
  • Evaluation of the level of advanced glycation end-products and antibodies against oxidized low-density lipoproteins in patients with neuroendocrine tumors
  • Assessment of oxidative and nitrosative stress markers in the blood of patients with neuroendocrine tumors
  • Evaluation of inflammatory state parameters in the blood of patients with Parkinson’s disease
  • Assessment of selected adipokine levels in the blood of patients with Parkinson’s disease
  • Assessment of melatonin and leptin levels in the blood of patients with Parkinson’s disease
  • Evaluation of adiponectin and resistin levels in the blood of patients with Parkinson’s disease
  • Correlation of vitamin D levels to the activity of antioxidative enzymes in the blood of healthy individuals
  1. Selected scientific publications:
  • Jarek, D.J.; Mizerka, H.; Nuszkiewicz, J.; Szewczyk-Golec, K. Evaluating P-Tau217 and p-Tau231 as Biomarkers for Early Diagnosis and Differentiation of Alzheimer’s Disease: A Narrative Review. Biomedicines 2024, 12, 786, doi:10.3390/biomedicines12040786.
  • Milanowski, J.; Nuszkiewicz, J.; Lisewska, B.; Lisewski, P.; Szewczyk-Golec, K. Adipokines, Vitamin D, and Selected Inflammatory Biomarkers among Parkinson’s Disease Patients with and without Dyskinesia: A Preliminary Examination. Metabolites 2024, 14, 106, doi:10.3390/metabo14020106.
  • Nuszkiewicz, J.; Kukulska-Pawluczuk, B.; Piec, K.; Jarek, D.J.; Motolko, K.; Szewczyk-Golec, K.; Woźniak, A. Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes. J. Clin. Med. 2024, 13, 4258, doi:10.3390/jcm13144258.
  • Milanowski, J.; Kozerawski, K.; Falęcka, W.; Dudek, D.; Lisewska, B.; Lisewski, P.; Nuszkiewicz, J.; Wesołowski, R.; Wojtasik, J.; Mila-Kierzenkowska, C.; et al. Changes in the Secretion of Melatonin and Selected Adipokines during the Progression of Parkinson’s Disease—Preliminary Studies. Metabolites 2023, 13, 668, doi:10.3390/metabo13050668.
  • Jarosław Nuszkiewicz, Agnieszka Kwiatkowska, Katarzyna Majko, Roland Wesołowski, Karolina Szewczyk-Golec, „Stres oksydacyjny i stan zapalny a rozwój otyłości: protekcyjne działanie melatoniny”, Problemy Higieny i Epidemiologii, 2017, 98(3): 226-232.
  • Dominika Tulska, Dominika Skonieczna, Jarosław Nuszkiewicz, Karolina Szewczyk-Golec, „Nowe markery użyteczne w prognozowaniu udaru niedokrwiennego mózgu”, MEDtube Science, 31 grudnia 2017 r., str. 94, suplement (MEDtube Science Dec, 2017; Vol. VII (4) Suppl.).
  • Jarosław Nuszkiewicz, Marta Pawłowska, Dominika Skonieczna, Daria Kupczyk, Karolina Szewczyk-Golec, „Wpływ suplementacji melatoniną na wybrane parametry stresu oksydacyjnego oraz stężenie adipokin u kobiet z otyłością prostą stosujących dietę o ograniczonej kaloryczności”, MEDtube Science, 31 grudnia 2017 r., str. 145, suplement (MEDtube Science Dec, 2017; Vol. VII (4) Suppl.).
  • Daria Malicka, Dominika Markowska, Jarosław Nuszkiewicz, Karolina Szewczyk-Golec, „Wpływ melatoniny na mechanizmy obrony antyoksydacyjnej w chorobie Alzheimera”, Postępy Higieny i Medycyny Doświadczalnej, 2018, 72: 1114-1122. DOI: 10.5604/01.3001.0012.8252.
  • Dominika Markowska, Daria Malicka, Jarosław Nuszkiewicz, Karolina Szewczyk-Golec, ,,Rola wybranych antyoksydantów w rozwoju i leczeniu choroby Parkinsona”, Postępy Higieny i Medycyny Doświadczalnej 2019, 73: 516-528. DOI: 10.5604/01.3001.0013.5252.
  • Daria Malicka, Dominika Markowska, Jarosław Nuszkiewicz, ,,Problematyka z zakresu medycyny i nauk pokrewnych – przegląd i badania. Tom 1”, tytuł rozdziału monografii: ,,Rola wybranych antyoksydantów i adipokin w prewencji i leczeniu choroby Parkinsona’’, Wydawnictwo Naukowe TYGIEL sp. z.o.o., data wydania: 15.09.2019 r.
  1. Selected scientific conferences:
  • Alicja Ziętara, Oliwia Kotowska, Marlena Budek, Jarosław Nuszkiewicz; „Evaluation of advanced glycation end product and antibodies against oxidized low-density lipoproteins levels in patients with neuroendocrine tumors based on tumor location”, 9th International Electronic Conference on Medicinal Chemistry 2023 – online – 01-30.11.2023 r. DOI: 10.3390/ECMC2023-15592
  • Barbara Zyśk, Jagoda Skrzeszewska, Marlena Budek, Karolina Szewczyk-Golec; „Evaluation of markers of oxidative and nitrosative stress in the blood of patients with neuroendocrine tumors”, 9th International Electronic Conference on Medicinal Chemistry 2023 – online – 01-30.11.2023 r. DOI: 10.3390/ECMC2023-15586
  • Paulina Mucha, Jan Milanowski, Jarosław Nuszkiewicz; „Lithium in the treatment of bipolar disorder”, National Scientific Conference „e-Factory of Science” VII edition – online – 09.04.2022 r.
  • Joanna Kruszka, Jarosław Nuszkiewicz; „Effect flavanols of Theobroma L. Beans on the cardiovascular system”, National Scientific Conference „e-Factory of Science” VII edition – online – 09.04.2022 r.
  • Dorian Jarek, Jarosław Nuszkiewicz, Karolina Szewczyk-Golec; ,,Alpha-synuclein and its role in neurodegenerative diseases”, National Scientific Conference „Understand the Science” V edition – online – 25.09.2021 r.
  • Oliwia Kotowska, Paulina Mucha, Jarosław Nuszkiewicz; ,,The role of vitamin D in the development of psoriasis”, National Scientific Conference „Understand the Science” V edition – online – 25.09.2021 r.
  • Jan Milanowski, Jarosław Nuszkiewicz, Karolina Szewczyk-Golec; ,,The role of leptin in the development and course of Parkinson’s disease’’, National Scientific Conference „Understand the Science” – online – 26.09.2020 r.
  • Dominik Dudek, Weronika Falęcka, Jan Milanowski, Jarosław Nuszkiewicz, Karolina Szewczyk-Golec; ,,Gene therapy in Parkinson s disease’’, National Scientific Conference „1st Summer Scientific On-line School” – on-line – 08.08.2020 r.
  • Weronika Falęcka, Dominik Dudek, Jan Milanowski, Jarosław Nuszkiewicz, Marlena Markiewicz, Karolina Szewczyk-Golec; ,,Role of the estrogenes in Parkinson s disease’’, National Scientific Conference „1st Summer Scientific On-line School” – on-line – 08.08.2020 r.
  • Jan Milanowski, Dominik Dudek, Weronika Falęcka, Jarosław Nuszkiewicz, Marlena Markiewicz, Karolina Szewczyk-Golec; ,,Bacteriocins and their therapeutic potential’’, National Scientific Conference „1st Summer Scientific On-line School” – on-line – 08.08.2020 r.
  • Jan Milanowski, Dominik Dudek, Weronika Falęcka, Jarosław Nuszkiewicz; ,,Colorectal cancer – new trends in diagnostics, treatment and their survival prognostic value’’, National Scientific e-Conference „e-Factory of Science” III edition –– on-line – 09.05.2020 r.
  • Weronika Falęcka, Dominik Dudek, Jan Milanowski, Jarosław Nuszkiewicz; ,,Role of prolactin and prolactin receptor in cancer progression’’, National Scientific e-Conference „e-Factory of Science” III edition –– on-line – 09.05.2020 r.
  • Dominik Dudek , Weronika Falęcka, Jan Milanowski, Jarosław Nuszkiewicz; ,,CRISPR-CAS – a new tool in diagnostics and treatment of viral and cancerous diseases’’, National Scientific e-Conference „e-Factory of Science” III edition –– on-line – 09.05.2020 r.
  • Daria Malicka, Dominika Markowska, Jarosław Nuszkiewicz; ,,Rola wybranych antyoksydantów i adipokin w prewencji i leczeniu choroby Parkinsona”, XI Interdyscyplinarna Konferencja Naukowa TYGIEL 2019 – Lublin, 23-24.03.2019 r.
  • Dominika Tulska, Dominika Skonieczna, Jarosław Nuszkiewicz, Karolina Szewczyk-Golec; „Nowe markery użyteczne w prognozowaniu udaru niedokrwiennego mózgu”, International Conference of Natural and Medical Sciences, Young Scientists, PhD Students and Students – Lublin, 01-03.12.2017 r.