SRC Vascular Biology

The Vascular Biology Student Scientific Club, founded in 2021 within the
Department of Histology and Embryology, is a vibrant and interdisciplinary
community committed to students with a keen interest in vascular biology.
The club actively engages in research pertaining to the intricacies of
blood vessel structure and function, as well as the processes integral to
their development and evolution.

The Club’s mission is to foster the scientific growth and collaboration of
both Polish- and English-speaking students, providing a platform for the
exchange of knowledge and experiences. Circle members have the chance to
engage in diverse research projects, attend scientific conferences, and
participate in workshops, thereby enhancing their competencies and honing
their research skills.

Furthermore, club members play an active role in research projects
dedicated to analyzing cellular responses to inflammatory factors. This
research involves observing changes in cell morphology induced by
inflammatory stress and analyzing alterations in vital functions, such as
gene expression, cytokine production, and modifications in cellular
structure.

Current research projects:

1. Assessment of the impact of the activity of tyrosine kinase inhibitors
on the secretory potential of coronary artery endothelial cells under
inflammatory response conditions – in vitro studies.

2. Cytoimmunological changes in bronchoalveolar lavage fluid (BAL) after
COVID-19 infection.

3. Evaluation of the effect of transcription factor KLF11 expression on
the inflammatory response of endothelial and smooth muscle cells of
coronary arteries induced by TNF-beta; and disruption of the
TGF-alpha;-SMAD signaling pathway.

4. Mechanobiology of the endothelial cell migration as a basis for the use
of biodegradable aliphatic polyester copolymers containing naturally
bioactive components in the design of cell scaffolds with increased
angiogenic potential of regenerated tissues.

Previous publications, presentations, other scientific achievements:

1. Mikołajczyk Klaudia, Spyt Dominika, Zielińska Wioletta, Żuryń
Agnieszka, Faisal Inaz*,Qamar Murtaz*, Świniarski Piotr, Grzanka Alina,
Gagat Maciej. The important role of endothelium and extracellular vesicles
in the cellular mechanism of aortic aneurysm formation. Int. J. Mol. Sci.
2021 : Vol. 22, nr 23, s. 1-15;, 13157.

2. Bonowicz Klaudia*, Mikołajczyk Klaudia*, Faisal Inaz*, Qamar Murtaz*,
Steinbrink K., Kleszczyński K., Grzanka Alina, Gagat Maciej. Mechanism of
extracellular vesicle secretion associated with TGF-beta-dependent
inflammatory response in the tumor microenvironment. Int. J.
Mol. Sci. 2022 : Vol. 23, nr 23, s. 1-12, 15335.

3. Piekarska Klaudia, Bonowicz Klaudia, Grzanka Alina, Jaworski Łukasz
M.*, Reiter R.J., Słomiński A.T., Steinbrink K., Kleszczyński K., Gagat
Maciej. Melatonin and TGF-beta mediated release of extracellular
vesicles. Metabolites. 2023: Vol. 13, nr 4, s. 1-20, 575.

Saving mode to SKN:
To join the group of active members of the Student Scientific Club of
Vascular Biology, please contact the chairman of the club and the
supervisor, and then complete the membership form available on the website
of the Student Scientific Society of the Collegium Medicum of the Nicolaus
Copernicus University.